Diabetes mellitus is an inheriting metabolic disorder; it may be caused due to fad diet, over eating, and insulin deficiency. If the patients are suffering with diabetes mellitus due to insulin deficiency they are classified under Type-I.
Type-I Diabetes mellitus; insulin should be externally before after 5-10 minutes of consuming meals. Let the patients keep in mind; they should not skip taking insulin dose. Type-I is otherwise called as juvenile diabetes.
Insulin Glargine injection is small insulin injections available in vials and ampoules. The storage condition of this injection is cool temperature. See that it does not get freeze, it may lose it pharmaceutical properties. It is synthetically prepared in which the chemical structure is similar to that of natural insulin hormone. While using this pharmaceutical preparation should be checked before using this injection. The injection should be clear without any gritty particles. It is better to discard the preparation and use another preparation.
The method of administration is through sub-cutaneous; it should be injected on different regions. Avoid injecting these injections in one targeted site; it may lead to lipid destruction. It is not advisable to rub on the skin where injection is carried out.
The activity that is seen after administration of this external insulin is; it catalyzes the conversion of high molecule to normal glucose molecules and finally relates in the production of energy to the functioning of body cells.
Regular usage of these insulin injections may lead to redness, rashes, itching and pain in the site of injection. If they lead to anaphylaxis it is better to discontinue the drug and seek medical support.
Insulin pump is being used by many people who are suffering from diabetes. As the device is user friendly and is very handy the users are extremely increasing in number.
The daily flexibility and the control of blood sugar can be managed by this device. At the same time it also reduces the effects that are related to low blood sugar. Nowadays this device has become more popular in the market for an artificial pancreas.
Maybe the most thrilling advancement in pump technology is the capability to use the pump with latest glucose sensing technology.
Glucose sensors have improved drastically from the last few years, and are an alternative for patients to get further close into their patterns of glucose response to tailor more personal treatment schedules.
The latest invention of sensors allows for an instant glucose amount to be given to the patient. The implantable sensor connects without a wire by a pager-sized device that has a display.
The device is kept near to the sensor to let device to pass on the data; though, it is a few feet distance, it can get the delivered information.
Basing on the type, the monitor shows the blood glucose reading, a thread of readings over time, and a probable rate of change in the glucose levels.
In this device we have a flexibility to design a program with the help of sensors which gives a beep when the blood sugar level goes extremely high or low. A few will be able to give a warning beep if the fall in blood sugar is taking place very fast.
Ø Insulin is the important drug that helps in the treating the diabetes mellitus. This is the hormone which helps in conversion of the blood glucose to glycogen. It is released from the beta cells of the endocrine part of the pancreatic gland in the human body.
Ø This transdermal patch is one of the drug delivery system in which the drug is diffused through the skin and activates at target desired. The drug penetrates through the bio-membrane i.e. skin. Here as the insulin is with higher molecular weight and larger in size, for this penetration it requires some applied force for the easy penetration of the drug, such as ultrasound, or by and electric current with lower voltage. Thus these drug delivery systems deliver the drug proteins (Insulin). The mechanism is known as the active transdermal delivery.
Ø This drug delivery can also be done by the Magnetophoresis; this is the enhancing of the drug through the biological membrane with the external magnetic field. Here the insulin drug is prepared as the transdermal patch but the force applied for the drug penetration is the magnetic field. This magnetophoretic drug permeation can be easily used by the patient on surface of the skin. This patch can be attached and detached easily.
Ø Onset of action is very fast, duration depends upon the dosage of the patch is with.
Ø Usage of the patch as directed by the physician.
Ø This flexible drug controlling devices is safe to use, and easy to carry.
You may be affected with diabetes if the presence of glucose in your blood is for longer time. If this is the case, there would many health complications. High glucose level in your blood can damage your heart, gums, teeth, eyes, kidneys, blood vessels.
People having Diabetes can have its effect on their feet also. Nearly 30 percent of the patients see few changes in their feet. Normally seen in the people whose age is more than 40 years. Diabetes can cause 2 problems in the feet; Poor circulation of the blood and the nerve damage.
Poor blood circulation: This happens when the blood is not properly flown to the feet and the legs. Lack of proper blood flow infects your heal and causes an impaired sensation in your feet. This type of condition is known as peripheral vascular disease. If the people suffering from diabetes smoke, the blood circulation can become worse.
Nerve damage: If nerves are broken in a Diabetic feet, you would not feel the pain in your leg or in your feet. But the cut on your feet might become worse as you do not know that you have Diabetes. Nerve damage results in lack of feelings. This condition is called Diabetic Neuropathy.
Diabetic feet can become worse with these 2 problems. If you have a blister on your feet because of the shoe, you might not feel the pain. This is because you have a damaged nerve in your feet. Due to this the blister gets infected. If the amount of sugar in your blood is high, this feeds the germs. The germs in your feet grow resulting in the infection. Due to which the blood flow decreases and it’s very difficult to heal the cut. The worsen infection causes gangrene. If a person is affected with gangrene, the skin around the cut dies and the area becomes smelly and black. A doctor needs to cut off the foot or the leg to prevent the spreading of gangrene.